Identification of widely conserved biosynthetic gene cluster involved in pigment production of <i>Bacillus subtilis</i>.

ABSTRACT: Bacillus subtilis is widely studied in the microbial secondary metabolite (SM) field due to its rich variety of important natural products and genetic tractability. We report a pigment observed in B. subtilis soil isolate MB9_B4 on certain media. We characterize the conditions where this pigment is produced and identify the corresponding biosynthetic gene cluster (BGC) using a comparative genomic approach exploiting our strain collection containing other isolates with pigment production ability. The responsible BGC carried several genes, which were annotated as parts of the tryptophan biosynthesis pathway, possibly originating from duplication and divergence of originally primary metabolism. Identification of the pigment gene cluster additionally led to the discovery of addit

SUBMITTER: Stannius RO 

PROVIDER: S-EPMC12282178 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature