Exploring the complex interplay between oral <i>Fusobacterium nucleatum</i> infection, periodontitis, and robust microRNA induction, including multiple known oncogenic miRNAs.

ABSTRACT: Fusobacterium nucleatum (F. nucleatum) is an oral commensal bacterium that can become pathogenic and is associated with periodontitis, adverse pregnancy outcomes, and colorectal cancer (CRC). MicroRNAs are conserved, non-coding RNA molecules that regulate gene expression and are detected in microbial infections. This study aims to characterize the microRNA expression kinetics in the mandibles of C57BL/6J mice infected with F. nucleatum for 8 and 16 weeks and to identify miRNAs as potential biomarkers using NanoString nCounter miRNA panels. Mice were divided into four groups: 8 weeks of infection, 16 weeks of infection, and their respective sham infection. F. nucleatum-infected mice showed 100% bacterial colonization on the gingival surface, along with a signific

SUBMITTER: Jeepipalli S 

PROVIDER: S-EPMC12282186 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature