Birds of a feather flock together: structural characterization of red-crowned crane and turkey aveparvoviruses.

ABSTRACT: The parvoviruses have non-enveloped T = 1 icosahedral capsids that are ~25 nm in diameter, which package linear single-stranded DNA and infect a wide range of hosts. To date, parvoviruses affecting birds have been identified in two genera: Ave- and Dependoparvovirus, and no capsid structures have been determined for any member of Aveparvovirus. This study investigates two bird viruses of this genus: red-crowned crane parvovirus (RCPV) and turkey parvovirus (TuPV). While the pathogenicity of RCPV is currently unknown, TuPV has been associated with gastrointestinal diseases, especially in juvenile birds. High-resolution structures of the RCPV and TuPV capsids were determined by cryo-electron microscopy at a resolution of 2.66 Å and 2.35 Å, respectively. A structur

SUBMITTER: Hsi J 

PROVIDER: S-EPMC12282197 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature