Genomic features of three major diarrhoeagenic <i>Escherichia coli</i> pathotypes in India.

ABSTRACT: Background. Diarrhoea remains a major threat to children in developing nations, with diarrhoeagenic Escherichia coli (DEC) being the primary causative agent. Characterizing prevalent DEC strains is crucial, yet comprehensive genomic analyses of major DEC strains, including enteropathogenic E. coli (EPEC), enteroaggregative E. coli (EAEC) and enterotoxigenic E. coli (ETEC), are lacking in India.Methods. We sequenced 24 EAEC and 23 EPEC strains from Indian patients with diarrhoea and conducted an extensive database search for DEC human isolates from India. Detailed phylogenetic analyses, virulence gene subtyping and examinations of accessory virulence and antimicrobial resistance (AMR) genes were performed.Results. The analysed DEC strains inc

SUBMITTER: Hoshiko Y 

PROVIDER: S-EPMC12282231 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature