Large-scale global molecular epidemiology of antibiotic resistance determinants in <i>Streptococcus pneumoniae</i>.

ABSTRACT: Streptococcus pneumoniae is a leading pathogen in terms of deaths attributable to or associated with antimicrobial resistance globally. Thus, monitoring antibiotic resistance determinants constitutes a key aspect of surveillance efforts for this microbe. Leveraging publicly available whole-genome sequencing (WGS) data, we aimed to investigate the presence and distribution patterns of antibiotic resistance determinants in S. pneumoniae with a focus on multidrug resistance (MDR) and serotype distribution. Metadata and genomes were obtained from the National Center for Biotechnology Information Pathogen Detection database. Curation and harmonization were performed in R and SPSS. Data on resistance patterns were defined according to AMRFinderPlus, and a combination of prediction

SUBMITTER: Shawrob KSM 

PROVIDER: S-EPMC12282287 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature