Timing and clinical significance of chemotherapy in patients with resected gastric adenocarcinoma: a population-based cohort study.

ABSTRACT:

Background

This study was to assess the impact of chemotherapy sequence on the prognosis of patients with gastric cancer (GC) undergoing gastrectomy and identify optimal chemotherapy timing along with potential candidates.

Patients and methods

Data on patients who underwent gastrectomy were extracted from Surveillance, Epidemiology, and End Results database. Prognostic factors for overall survival (OS) were assessed using Kaplan-Meier and Cox regression analyses. Treatment strategies were categorized into neoadjuvant chemotherapy (NAC), adjuvant chemotherapy (AC), and perioperative chemotherapy (PC), with subsequent analyses of clinical outcomes. Stable inverse probability of treatment weighting (sIPTW) and subgroup analyses were conducted to evaluate the significance of che

SUBMITTER: Zhang D 

PROVIDER: S-EPMC12282361 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature