Multivariate patterns linking brain microstructure to temperament and behavior in adolescent eating disorders.

ABSTRACT: Eating disorders (EDs) are multifaceted psychiatric disorders characterized by varying behaviors, traits, and cognitive profiles driving symptom heterogeneity and severity. Non-invasive neuroimaging studies have been critical to elucidate the neurobiological circuitry involved in ED-related behaviors, but often focused on a limited set of regions of interest and/or symptoms. The current study harnesses multivariate methods to map microstructural and morphometric patterns across the entire brain to multiple domains of behavior and symptomatology in adolescents with EDs. Diffusion-weighted images, modeled with restriction spectrum imaging, were analyzed for 91 adolescents with an ED and 48 healthy controls. Partial least squares analysis was applied to map 38 behavioral measures (encompassin

SUBMITTER: Makowski C 

PROVIDER: S-EPMC12282504 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature