Prenatal black carbon exposure and DNA methylation in umbilical cord blood.

ABSTRACT:

Background/objectives

Prenatal exposure to ambient air pollution is associated with adverse cardiometabolic outcomes in childhood. We previously observed that prenatal black carbon (BC) was inversely associated with adiponectin, a hormone secreted by adipocytes, in early childhood. Changes to DNA methylation have been proposed as a potential mediator linking in utero exposures to lasting health impacts.

Methods

Among 532 mother-child pairs enrolled in the Colorado-based Healthy Start study, we performed an epigenome-wide association study of the relationship between prenatal exposure to a component of air pollution, BC, and DNA methylation in cord blood. Average pregnancy ambient BC was estimated at the mother's residence using a spatiotemporal prediction model. DNA methylat

SUBMITTER: Friedman C 

PROVIDER: S-EPMC12282525 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature