Genetic Associations of Rod- and Cone-Mediated Vision in Aging and Age-Related Macular Degeneration.

ABSTRACT:

Purpose

To compare genetic associations of rod- and cone-driven vision with those previously defined for delayed rod-mediated dark adaptation (RMDA), a functional risk indicator for incident age-related macular degeneration (AMD).

Methods

In adults aged ≥60 years with two normal eyes (per the Age-Related Eye Disease Study 9-step scale) or with AMD in one or both eyes, we measured RMDA at 5° superior retina, photopic vision (acuity, contrast sensitivity, light sensitivity), and mesopic vision (low luminance acuity and deficit). Vision associations of risk-conferring single-nucleotide polymorphisms in CFH and ARMS2 genes were adjusted for age and smoking and stratified for the presence of subretinal drusenoid deposit (SDD).

Results

Of 608 participants, 462 had normal ma

SUBMITTER: Curcio CA 

PROVIDER: S-EPMC12282642 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature