Trifluoroacetyl-Substituted D-π-A Fluorophores: Design Strategies for Strong Solvatochromism and Giga Stokes Shifts.

ABSTRACT: Solvatochromic fluorophores, widely employed in various analytical applications such as environmentally responsive dyes, typically feature a donor-π-acceptor (D-π-A) structure. Most recently, Klymchenko and we independently designed D-π-A fluorophores with a strong acceptor, trifluoroacetyl group, to achieve strong fluorescent solvatochromism and reported its application to membrane analysis (Klymchenko et al. Anal. Chem. 2024, 96, 13242) and molecular thermometer (Konishi et al. J. Am. Chem. Soc. 2025, 147, 9953), respectively. However, these reports have only considered a few π-electron donors including dialkylamines. There is not enough scope for solvatochromic fluorophores that take advantage of the properties of the trifluoroacetyl group. In this study, we systematically investigated

SUBMITTER: Hori A 

PROVIDER: S-EPMC12282648 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature