Exploring the potential causal association between genetic factors for multiple sclerosis and genetic factors for kidney disease: A multivariate Mendelian randomization study.

ABSTRACT: The potential causal relationship between genetic susceptibility to multiple sclerosis (MS) and the risk of kidney diseases remains unclear. Understanding this association may provide new insights into comorbidity mechanisms and improve clinical risk assessment. A two-sample Mendelian randomization (MR) analysis was conducted using single nucleotide polymorphisms significantly associated with MS as instrumental variables. Genetic data were derived from genome-wide association studies comprising 115,803 individuals for MS and up to 218,792 individuals for renal diseases. Outcomes included nephrotic syndrome, glomerulonephritis, tubulointerstitial nephritis, and diabetic nephropathy. Causal estimates were calculated using inverse variance weighted, MR-Egger, weighted median, and simple mode

SUBMITTER: Peng S 

PROVIDER: S-EPMC12282742 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature