Different SARS-CoV-2 variants inhibited by RRM designed peptide.

ABSTRACT: The SARS-CoV-2 virus has mutated over time, resulting in variations of circulating viral variants, which may impact the virus's properties, such as transmission or the severity of symptoms. Thus, there is a need for comprehensive approach less dependent of viral variants. For that purpose, we have employed the innovative and unique Resonant Recognition Model (RRM) to identify the common characteristics of all variants of SARS-CoV-2 virus and based on these characteristics, we have explored the possibility to develop approach against SARS-CoV-2 infection, less dependent on viral variants. This paper is a continuation of our previous research, where we have used the RRM model to design de novo peptide CovA, capable to prevent SARS-CoV-2 interaction with ACE2 receptor on host cells. Using Inh

SUBMITTER: Krapez U 

PROVIDER: S-EPMC12282855 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature