Genome-scale metabolic modelling of human gut microbes to inform rational community design.

ABSTRACT: The human gut microbiome impacts host health through metabolite production, notably short-chain fatty acids (SCFAs) derived from digestion-resistant carbohydrates (DRCs). While DRC supplementation offers a means to modulate the microbiome therapeutically, its effectiveness is often limited by the microbial community's complexity and individual variability in microbiome functionality. We utilized genome-scale metabolic models (GEMs) from the AGORA collection to provide a system-level overview of the metabolic capabilities of human gut microbes in terms of carbohydrate trophic networks and propose improved therapeutic interventions, based on microbial community design. Our study inferred the capability of AGORA strains to consume carbohydrates of varying structural complexities - including D

SUBMITTER: Molina Ortiz JP 

PROVIDER: S-EPMC12283000 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature