A genome-wide association study implicates the olfactory system in <i>Drosophila melanogaster</i> diapause-associated lifespan extension and fecundity.

ABSTRACT: The effects of environmental stress on animal life are gaining importance with climate change. Diapause is a dormancy program that occurs in response to an adverse environment, followed by resumption of development and reproduction upon the return of favorable conditions. Diapause is a complex trait, so we leveraged the Drosophila Genetic Reference Panel (DGRP) lines and conducted a genome-wide association study (GWAS) to characterize the genetic basis of diapause. We assessed post-diapause and non-diapause fecundity across 193 DGRP lines. GWAS revealed 546 genetic variants, encompassing single nucleotide polymorphisms, insertions, and deletions associated with post-diapause fecundity. We identified 291 candidate diapause-associated genes, 40 of which had previously been associated with di

SUBMITTER: Easwaran S 

PROVIDER: S-EPMC12283071 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature