The Negative Feedback of the Glutamine/Prostatitis Loop Identified Among 1400 Metabolites and Prostatitis via Mendelian Randomization.

ABSTRACT: Background: Prostatitis remains a clinically tricky problem due to its enigmatic etiologies, low cure rates, and relatively high recurrence rates. Therefore, we first employed Mendelian randomization to disclose the causal relationships among 1400 metabolites and prostatitis for a better understanding of the etiologies of prostatitis and thus identifying effective therapeutic targets. Methods: Prostatitis or metabolite-related data were derived from the online FinnGen or genome-wide association study (GWAS) Catalog datasets. Two-sample Mendelian randomization was employed, and sensitivity analyses, including heterogeneity, pleiotropy, and leave-one-out analysis, were applied to evaluate its stability. Results: Four potentially metabolic etiologies were identified for p

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12283193 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature