The association between high atherogenic index of plasma and impaired lung function: a population-based study.

ABSTRACT:

Objective

Although AIP is a recognized cardiovascular risk marker, its association with pulmonary function and sex-specific differences remains unclear. This study investigated whether elevated AIP is independently associated with reduced lung function and examined potential sex-specific patterns.

Methods

Data from 4,565 participants in the NHANES 2007-2012 dataset were analyzed using a cross-sectional design. AIP served as the exposure variable, with five lung function metrics (including FEV₁, FVC, and FEV₁/FVC ratio) as outcomes. Weighted multiple linear regression, threshold effect analysis, subgroup comparisons, and XGBoost modeling were performed to assess associations.

Results

Multivariable regression showed a significant negative associati

SUBMITTER: Yang L 

PROVIDER: S-EPMC12283284 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature