Endothelial activation and stress index for prediction of mortality in asthma.

ABSTRACT:

Background

EASIX (Endothelial Activation and Stress Index) has been shown to be associated with the prognosis of various diseases in numerous studies, but its relationship with short- and medium-term outcomes in asthma patients admitted to the ICU (Intensive Care Unit) remains unclear.

Methods

This retrospective cohort study included 3,737 asthma patients from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database (2008-2019). We calculated log2(EASIX) using platelet count, creatinine, and lactate dehydrogenase levels measured on ICU admission day 1. We analyzed the association between log2(EASIX) and 28-day and 60-day in-hospital mortality using multivariable Cox regression and restricted cubic splines. Proportional hazards assumptions were tested to ensure

SUBMITTER: He Y 

PROVIDER: S-EPMC12283289 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature