Population pharmacokinetic analysis of remimazolam after continuous infusion for sedation in critically ill patients.

ABSTRACT:

Introduction

The aim of the present prospective study was to model the population pharmacokinetics of remimazolam after continuous infusion in critically ill patients, and to provide a guide for remimazolam administration based on simulations that were conducted.

Patients and methods

A total of 32 critically ill patients were enrolled in this study, with 236 plasma concentration data ultimately included for modeling. Plasma concentrations of remimazolam were quantified by a validated high-performance liquid chromatography-tandem mass spectrometry method, and the data were analyzed using non-linear mixed effect modeling. Concentration-time curves of remimazolam at different induction and maintenance doses were simulated and context-sensitive decrement times (CSDTs) were calcu

SUBMITTER: Chen J 

PROVIDER: S-EPMC12283299 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature