Raider of the lost <i>N-</i>glycans - Localizing rare and frequently overlooked IgG <i>N-</i>glycans with sulfation or bisecting LacNAc.

ABSTRACT: Immunoglobulin G (IgG) is the most abundant immunoglobulin in human blood. Here it plays a central role in the immune system by recognizing antigens and mediating effector functions of the humoral immune defense. The role of IgG N-glycosylation in many of these processes is well known. However, low-abundant N-glycans with special features, like sulfation or galactosylated bisecting N-acetylglucosamine (GlcNAc), are rarely accounted for due to their challenging detection. These structures are frequently overlooked and their presence on IgG is disputed mainly because specialized enrichment and analysis strategies are required for their detection. Consequently, they are disregarded in studies of IgG N-glycosylation, which in general is well understood. But function

SUBMITTER: Burock R 

PROVIDER: S-EPMC12283335 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature