Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry.

ABSTRACT: Age at onset of walking is an important early childhood milestone which is used clinically and in public health screening. In this genome-wide association study meta-analysis of age at onset of walking (N = 70,560 European-ancestry infants), we identified 11 independent genome-wide significant loci. SNP-based heritability was 24.13% (95% confidence intervals = 21.86-26.40) with ~11,900 variants accounting for about 90% of it, suggesting high polygenicity. One of these loci, in gene RBL2, co-localized with an expression quantitative trait locus (eQTL) in the brain. Age at onset of walking (in months) was negatively genetically correlated with ADHD and body-mass index, and positively genetically correlated with brain gyrification in both infant and adult brains. The polygenic score showed ou

SUBMITTER: Gui A 

PROVIDER: S-EPMC12283345 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature