Ultraviolet exposure of mice fed a high fat diet reduces weight gain and markers of liver disease progression.

ABSTRACT:

Background

Research suggests that ultraviolet (UV) exposure of mice placed on a high fat diet can reduce incidence of metabolic disease. However, current research had primarily focused on male mice with UV outside level of terrestrial sunlight.

Objectives

Here we attempt to address this imbalance, with a pilot study presented wherein female mice C57Bl6 mice are included, with UV exposure at level comparable to low dose (non-burning) sunlight exposure.

Methods

2% UV-B and 98% UV-At a dose of 1.83 J/cm² with UV-A and 0.04 J/ cm² UV-B were delivered over a 10-min timeframe twice weekly. Mice were placed on a low-fat diet or high fat diet, with the high fat diet cohort either exposed twice weekly to UV light or sham exposed.

Results

Non-signif

SUBMITTER: Hazell G 

PROVIDER: S-EPMC12283362 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature