An international Delphi consensus for reporting of setting in psychedelic clinical trials.

ABSTRACT: Psychedelic substances exhibit complex interactions with the 'set and setting' of use, that is, the mental state of the user and the environment in which a psychedelic experience takes place. Despite these contextual variables' known importance, psychedelic research has lacked methodological rigor in reporting extra-pharmacological factors. This study aimed to generate consensus-based guidelines for reporting settings in psychedelic clinical research, according to an international group of psychedelic researchers, clinicians and past trial participants. We conducted a Delphi consensus study composed of four iterative rounds of quasi-anonymous online surveys. A total of 89 experts from 17 countries independently listed potentially important psychedelic setting variables. There were 770 resp

SUBMITTER: Pronovost-Morgan C 

PROVIDER: S-EPMC12283393 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature