Dysregulated maternal and newborn fatty acid, sugar and amino acid metabolism associated with high birth weight.

ABSTRACT:

Objective

This study aims to find maternal and neonatal metabolomic signatures that contribute to the adverse birthweight outcomes including abnormally high and low birth weight. We also investigated the role of metabolomic signatures in the associations of maternal risk factors such as parity and gestational weight gain with adverse birthweight outcomes.

Methods

Ninety-six pregnant women and their newborns from the MADRES prospective cohort were studied. Maternal serum at third trimester and newborn cord blood were assayed for untargeted metabolomics using mass-spectrometry. Metabolome-wide association analysis was conducted to assess maternal and newborn metabolomic features association with birth weight Z-score, followed by network analysis of maternal and newborn metabol

SUBMITTER: Qiu C 

PROVIDER: S-EPMC12283401 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature