Genomic mutation profile and metabolic alterations in diffuse large B-cell lymphoma with abdominal bulky mass.

ABSTRACT: Diffuse large B-cell lymphoma (DLBCL) is a tumor with significant clinical and genetic heterogeneity. DLBCL with bulky mass (≥ 7.5 cm) exhibits a negative prognostic impact. Due to the low incidence and the lack of relevant studies, the drivers and characteristic genetic mutations of DLBCL with abdominal bulky mass (DLBCL-AB) remain unclear. To explore individualized treatment strategies by analyzing genomic mutation profile and characteristic biological alterations in DLBCL-AB may help to optimize patients' prognosis. Next-generation sequencing of tumor tissues from 39 patients (29 with DLBCL-AB and 10 with common DLBCL) was performed to screen mutation profiles. Three platforms, gas chromatography-mass spectrometry (GC-MS), high-resolution liquid chromatography-mass spectrometry (LC-MS p

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12283436 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature