The role of LAMA5 in breast cancer progression and its potential in immunotherapy.

ABSTRACT:

Background

Laminin alpha-5 (LAMA5), a major extracellular matrix component, is involved in tumor progression by modulating cell adhesion, migration, and tissue architecture. However, its specific role in breast cancer (BRCA) remains unclear.

Methods

We analyzed LAMA5 expression in BRCA and normal tissues using TCGA and GTEx datasets. Differential expression analysis was conducted using DESeq2. Survival associations were assessed using Kaplan-Meier and Cox regression models. GSEA was performed to identify LAMA5-related biological pathways. Immune infiltration was evaluated using CIBERSORT and ESTIMATE algorithms. Single-cell RNA sequencing and spatial transcriptomics were used to explore the spatial distribution and cellular localization of LAMA5. Drug sensitivity and immunot

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12283511 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature