Moderate-intensity exercise training uniquely modulates circulating lipid species beyond classical lipid levels in humans.

ABSTRACT:

Background

Regular physical exercise shows significant health-related benefits, potentially through the modulation of lipid metabolism in an intensity-dependent manner.

Methods

In this study, we profiled 794 plasma lipid species across 18 subclasses following a 24-week supervised concurrent and randomised exercise intervention at moderate and vigorous intensities in 101 young, sedentary adults.

Findings

Here, we demonstrate that moderate-intensity exercise, but not vigorous-intensity, significantly increased plasma levels of glycerophospholipids and triacylglycerol species. Interestingly, we also identified a sex-specific response to moderate-intensity exercise, with men exhibiting elevated glycerophospholipids and lysophospholipids species, and women showing signific

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12283555 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature