Prognostic significance and immune infiltration analysis of HMGA2 in endometrial cancer.

ABSTRACT:

Background

HMGA2, as a transcription factor, facilitates oncogenesis and malignant progression by coordinating cell cycle dysregulation, compromising DNA repair machinery, and suppressing cancer cell apoptosis. However, its roles in prognostication and tumor immune microenvironment modulation in endometrial cancer (EC) remain incompletely defined.

Methods

We systematically analyzed HMGA2 expression patterns and clinical prognostic value in EC using bioinformatics strategies, including TCGA and GTEX data mining, as well as single gene expression analysis. Functional enrichment analysis (GSEA and KEGG) identified HMGA2-associated pathways. The correlation between HMGA2 and immune infiltration was assessed via TIMER and TISIDB. Subsequent in vitro (proliferation, migrati

SUBMITTER: Jiang P 

PROVIDER: S-EPMC12283574 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature