Efficacy of therapies for intermediate-stage hepatocellular carcinoma: systematic review and network meta-analysis.

ABSTRACT:

Background

Transarterial chemoembolization (TACE) is recommended for intermediate-stage hepatocellular carcinoma (HCC). However, several therapies have shown better efficacy than TACE, meaning that the optimal therapy is unclear. We addressed this uncertainty using network meta-analysis (NMA).

Methods

A literature review was performed up to March 15, 2024. Efficacy was evaluated using overall survival (OS) and progression-free survival (PFS). The hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted from the Kaplan-Meier curves. A random-effects NMA was conducted, and subgroup analysis was performed according to the tumor number, tumor size, viral etiology, and alpha fetoprotein (AFP) level. The efficacy of the different therapies was ranked based on the P

SUBMITTER: Zong S 

PROVIDER: S-EPMC12283577 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature