Co-delivery of anti-inflammatory and antioxidant agents via polymersomes for osteoarthritis therapy.

ABSTRACT:

Background

Osteoarthritis (OA) is a chronic degenerative joint disease primarily driven by inflammation and oxidative stress. This study aimed to develop a polymersome-based co-delivery system encapsulating hydrophilic cordycepin and hydrophobic phenylboronic acid (PBA) to enhance their solubility, stability, and therapeutic efficacy against OA.

Methods

Formulation parameters were optimized using a Taguchi orthogonal design to achieve high encapsulation efficiency, sustained drug release, and effective reactive oxygen species (ROS) scavenging. In vitro anti-inflammatory effects were evaluated in LPS-activated RAW 264.7 macrophages by assessing TNF-α, IL-1β, and extracellular ROS levels. Therapeutic efficacy was further validated in a papain-induced OA rat model treate

SUBMITTER: Rui M 

PROVIDER: S-EPMC12283600 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature