Examining the mediating function of SIRI in the association between LC9 and chronic obstructive pulmonary disease.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is a major contributor to early mortality, high overall mortality rates, and significant healthcare costs. Based on the Life's Essential 8 (LE8), Life's Crucial 9 (LC9) is a new cardiovascular health evaluation instrument that also includes a mental health examination, while the systemic inflammation response index (SIRI) is an emerging biomarker of systemic inflammation. The purpose of this study is to look at the link between LC9 and COPD and how SIRI may play a mediating function in it.

Methods

Data from 25,721 U.S. participants in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018 were used in a cross-sectional study. To investigate the relationship between COPD and LC9, multivariable lo

SUBMITTER: Wang Z 

PROVIDER: S-EPMC12283655 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature