CXCL16/CXCR6 axis arises as a potential peripheral biomarker of early COPD development - results from a pilot study.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is mainly caused by long-term exposure to cigarette smoke. Since systemic inflammation is an important component of COPD pathophysiology, its characterization is essential for developing new biomarkers and pharmacological approaches. We have previously reported CXCL16/CXCR6 axis upregulation, a key element of leukocyte trafficking in COPD. Given the paucity of data on early-stage COPD patients (GOLD 1), we investigated CXCL16/CXCR6 axis expression in this population and in individuals at risk for developing COPD.

Design

Blood samples were collected from 27 GOLD 1 patients, 27 symptomatic smokers with normal lung function (pre-COPD), and 14 non-smokers. CXCR6 expression was assessed in platelets, leukocytes, and leukocyt

SUBMITTER: Marques P 

PROVIDER: S-EPMC12283661 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature