Engineering ROS-responsive double network hydrogel as bioactive barrier for postoperative abdominal adhesions prevention.

ABSTRACT: Postoperative adhesions are common and severe complications, which affect up to 90 % of patients undergoing abdominal surgery. Despite the application of various strategies to minimize adhesions, the clinical outcomes remain far from satisfactory. Herein, we engineered a ROS-responsive and scavenging double-network hydrogel (PD-OHN) with multiple biofunctions and good mechanical properties for effective PAA prevention. First, a novel ROS-cleavable dithiothreitol (DTT) crosslinking monomer (DPBA) was synthesized. Subsequently, PD-OHN hydrogel was fabricated within 5 s by forming phenylborate ester bond networks between DPBA and polyvinyl alcohol (PVA), and acylhydrazone bond networks between oxidized hyaluronic acid (OHA) and adipic acid dihydrazide-modified hyaluronic acid (HA-ADH). After

SUBMITTER: Ren L 

PROVIDER: S-EPMC12283673 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature