Prognostic value of the serum creatinine/albumin ratio for 28-day mortality in heart failure: a retrospective cohort study.

ABSTRACT:

Background

Heart failure (HF) is a global health challenge with high morbidity and mortality. The serum creatinine/albumin ratio (CAR), a marker of renal dysfunction and malnutrition, has shown prognostic value in other critical illnesses but remains underexplored in HF patients.

Methods

This retrospective cohort study included 1,893 HF patients hospitalized at the Fourth People's Hospital of Zigong, China, between December 2016 and June 2019. Cox proportional hazards models assessed the association between CAR and 28-day mortality. Dose-response relationship was assessed using restricted cubic spline analysis, Kaplan-Meier curves illustrated survival differences, and Receiver Operating Characteristic (ROC) analysis evaluated CAR's predictive performance.

Results

Pati

SUBMITTER: Luo H 

PROVIDER: S-EPMC12283707 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature