Clinical, immunological, and genetic landscape of common variable immunodeficiency in Morocco: a nationwide multicenter study.

ABSTRACT:

Background

Common Variable Immunodeficiency (CVID) is the most prevalent symptomatic inborn errors of immunity (IEI), characterized by impaired antibody production, recurrent infections, and immune dysregulation. While extensively studied in Western populations, data from North Africa remains scarce. This study provides the first comprehensive evaluation of the clinical, immunological, and genetic landscape of CVID in a Moroccan nationwide cohort.

Methods

A multicenter, cross-sectional study was conducted across eight university hospitals in Morocco from 2019 to 2025. Sixty-one CVID patients were enrolled according to ESID (European society of immunodeficiency) and MENA (Middle-East and North Africa) guidelines. Clinical, immunological, and genetic data were analyzed. Whole-

SUBMITTER: Allaoui A 

PROVIDER: S-EPMC12283719 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature