Case Report: Rescue "awake" extracorporeal membrane oxygenation for acute respiratory failure in severe granulomatosis with polyangiitis with multisystem involvement.

ABSTRACT: We present the case of a 40-year-old man who developed severe acute respiratory failure along with hemoptysis and was subsequently diagnosed with granulomatosis with polyangiitis (GPA). He was initially treated with high-dose corticosteroids, cyclophosphamide, plasmapheresis, and mechanical ventilation (MV). The patient's condition deteriorated after being weaned from MV, leading to his transfer to our medical center without reintubation. Upon admission, a high-flow nasal cannula delivering FiO2 of 1.0 was immediately initiated. Despite the severity of hypoxemia, the patient exhibited neither tachypnea nor subjective dyspnea, and was subsequently initiated on "awake" venovenous extracorporeal membrane oxygenation (VV-ECMO) without MV. Anticoagulation therapy was initiated, and continuous r

SUBMITTER: Kim T 

PROVIDER: S-EPMC12283735 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature