An electrochemical aptasensor for detection of <i>Helicobacter pylori</i> based on AuNPs and AgNPs-GO nanoparticles.

ABSTRACT: Helicobacter pylori is one of the main causes of gastritis and gastric ulcer. Early detection of H. pylori is of great significance for the prevention of gastric cancer. Herein, a sensitive electrochemical aptasensor using AgNPs-GO as redox probes was established for the specific detection of H. pylori in blood serum and stool samples. Firstly, AgNPs-GO nanocomposites were obtained by in-situ reduction of AgNPs on graphene oxide (GO) surface with glucose as reducing agent, in which AgNPs showed good biocompatibility and chemical stability, as well as redox property, and GO provided a large surface area to assemble a large number of AgNPs. Subsequently, the electrodeposition of AuNPs further improved the conductivity of the aptasensor. Additionally, the streptavidin was

SUBMITTER: You X 

PROVIDER: S-EPMC12283743 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature