Single-cell transcriptional landscape of peripheral myeloid cells in autoimmune diseases.

ABSTRACT: Myeloid cells are pivotal in autoimmune disorder development due to their varied immune response functions yet understanding them at the single-cell level in such conditions is limited. To address this gap, we analyzed 351,905 myeloid cells from 375 single-cell RNA sequencing samples covering 14 autoimmune diseases, which allowed us to classify myeloid cells into 13 distinct subsets with unique immunological profiles. Through pseudotime analysis, we identified a branching process leading to two intermediary inflammatory subtypes and observed dysregulation in eight co-expression modules crucial for monocyte function across autoimmune conditions. Notably, a module linked to myeloid cell activation was consistently upregulated in autoimmune disorders. This insight led us to identify potential

SUBMITTER: Wang FQ 

PROVIDER: S-EPMC12283746 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature