Adverse events of pharmacological interventions for insomnia disorder in adults: a systematic review and network meta-analysis.

ABSTRACT:

Background

The clinical decision-making to insomnia drugs should comprehensively weight its risks.

Objective

To perform a systematic review and network meta-analysis of randomized controlled trials to compare the AEs associated with different insomnia drugs for adults with insomnia.

Methods

We conducted Bayesian network meta-analyses and fixed-effects Mantel-Haenszel network meta-analyses to estimate the relative safety between treatments.

Results

Compared with placebo, zolpidem (somnolence: relative risk [RR] 1.85; dizziness: RR 2.33; headache: RR 1.26), zopiclone (somnolence: RR 2.02; dizziness: RR 2.33; dysgeusia: RR 7.84), indiplon (somnolence: RR 3.46; dizziness: RR 2.30; headache: RR 1.63), gaboxadol (dizziness: RR 3.44), eszopiclone (somnolence: RR 2.00;

SUBMITTER: Lu C 

PROVIDER: S-EPMC12283787 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature