Coupling chromosome organization to genome segregation in Archaea.

ABSTRACT: Chromosome segregation is a fundamental process in all life forms and requires coordination with genome organization, replication and cell division. The mechanism that mediates chromosome segregation in archaea remains enigmatic. Previously, we identified two proteins, SegA and SegB, which form a minimalist chromosome partition machine in Sulfolobales. Here we uncover patterns and mechanisms that SegAB employ to link chromosome organization to genome segregation. Deletion of the genes causes growth and chromosome partition defects. ChIP-seq investigations reveal that SegB binds to multiple sites scattered across the chromosome, but mainly localised close to the segAB locus in most of the examined archaeal genera. The sites are predominantly present in intragenic regions and enriched in one

SUBMITTER: Kabli AF 

PROVIDER: S-EPMC12284271 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature