Hybrid proton planning combining spread-out Bragg peak beams with transmission beams to shorten field delivery times while maintaining plan quality.

ABSTRACT:

Background and purpose

Delivery times of Bragg-peak-based intensity-modulated proton therapy fields play an important role in patient throughput and comfort. Despite the associated exit dose, single-layer proton transmission beams benefit from sharper penumbras and are extremely fast to deliver. In this study, we investigated the trade-offs in field delivery times (FDT) and plan quality when using both field types.

Materials and methods

Reference treatment plans were created for eight left-sided breast and ten oropharynx cancer patients using an in-house automatic iterative optimizer. Comparative hybrid plans were created for each case. For breast, different combinations of transmission and conventional beams were evaluated. For oropharynx, two of the three conventional beam

SUBMITTER: Hytonen R 

PROVIDER: S-EPMC12284364 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature