Optogenetic modulation of peripheral nociceptive neurons with biocompatible optoelectronic implants.

ABSTRACT: Hyperexcitability of peripheral sensory neurons plays a critical role in the development and maintenance of chronic pain. Pharmacological analgesics used in clinics reduce neuronal activity. They often come with non-negligible side effects. Optogenetic approaches can modulate neuronal activity and are attracting growing interest for therapeutic uses, but the delivery of light in different parts of the body requires the development of specific optoelectronic interfaces. We designed and produced a microfabricated optoelectronic implant to deliver yellow light (559 nm) onto the sciatic nerve. We have surgically implanted the device in transgenic mice expressing the yellow light-sensitive inhibitory archaerhodopsin (ArchT) in nociceptive neurons. Yellow light induced a significant reduction in

SUBMITTER: Chung PCS 

PROVIDER: S-EPMC12284439 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature