Distinct impacts of sodium channel blockers on the strength-duration properties of human motor cortex neurons.

ABSTRACT:

Objective

This study was undertaken to determine how voltage-gated sodium channel (VGSC) blockers modulate cortical excitability in vivo. VGSCs are critical for regulating axonal excitability, yet the effects of sodium channel-blocking medications on human cortical neurons remain poorly characterized. We aimed to address this gap using transcranial magnetic stimulation (TMS)-derived strength-duration measures as a noninvasive index of VGSC function.

Methods

Thirteen healthy adults received single doses of either carbamazepine, lacosamide, or placebo in a crossover design. TMS was used to assess changes in resting motor threshold and strength-duration properties, including rheobase and the strength-duration time constant, as indices of VGSC function.

Results

Both medic

SUBMITTER: Rocchi L 

PROVIDER: S-EPMC12284445 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature