Engineering NO delivery system renormalizes the excitability of inhibitory interneurons after spinal cord injury <i>via</i> chloride extrusion.

ABSTRACT: Spinal cord injury (SCI)-induced severe neurological deficits arise from persistent ionic dysregulation and the dysfunction of inhibitory interneurons. Nitric oxide (NO) serves as a critical second messenger in ion channel modulation, yet its therapeutic potential in SCI-associated ionic dysregulation remains unexplored. In this study, an octahedral palladium nanozyme and L-Arg composite hydrogel (o-Pd/Arg^gel) that achieves spatiotemporally controlled NO release while catalytically neutralizing the hazardous by-products of NO was engineered. o-Pd/Arg^gel orchestrates dual neurovascular repair through augmenting endothelial nitric oxide synthase (eNOS) expression to enhance endothelial cell survival and stimulate brain-derived neurotrophic factor (BDNF) se

SUBMITTER: Wu S 

PROVIDER: S-EPMC12284487 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature