Rescuing inflammatory microenvironment induced senescence via MgO immune mediated asymmetric short fibers for accelerating diabetic wound repair.

ABSTRACT: Ongoing disturbance of the immune microenvironment under diabetes mellitus is a significant obstacle to optimal wound repair. Persistence of the local inflammatory niche from incomplete or dysregulated regression of acute inflammation causes the surrounding tissues to undergo immune-induced senescence. Inspired by the natural tissue structure of the extracellular matrix and metal immunotherapy, we developed an asymmetric short-fiber Gelatin/Poly(L-lactic acid) aerogel scaffold loaded with magnesium oxide nanoparticles (GP@MgO aerogel). This innovative short-fiber aerogel scaffold addresses the two-dimensional longitudinal collapse of electrospinning. It achieves a spatial three-dimensional bionic structure that provides additional cell adhesion sites and slowly absorbs tissue exudates. The

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12284504 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature