Short-term Tolerance to Inhaled Antibiotics in Patients With Bronchial Infection not Associated With Cystic Fibrosis.

ABSTRACT:

Introduction

The use of intravenous antibiotic formulations delivered by inhalation is controversial. Tolerance can be an issue and some treatment guidelines discourage this route of administration if the same antibiotic is available in an inhalation formulation.

Material and methods

This was a retrospective, observational, single-center study comparing tolerance to three antibiotics delivered by nebulization (intravenous formulations of ampicillin and gentamicin, and an inhalation formulation of colistimethate sodium) in patients with bronchial infection (BI), chronic bronchial infection (CBI), and/or recurrent respiratory infections. The study also aimed to identify factors potentially associated with tolerability.

Results

A total of 330 antibiotic tolerance tests w

SUBMITTER: Maiz L 

PROVIDER: S-EPMC12284521 | biostudies-literature | 2025 Jul-Sep

REPOSITORIES: biostudies-literature