Multifunctional nanogel dressings with dual acid and H₂O₂ responsive release for synergetic therapy of diabetic bacterial wounds.

ABSTRACT: The high sugar and alkaline environment at diabetic skin wounds promotes the breeding and reproduction of bacteria, leading to insufficient angiogenesis, which seriously affects wound healing. To accelerate wound healing, MnO₂ nanoparticles (MnO₂ NPs) and glucose oxidase (GOD) were added into the acidic and hydrogen peroxide (H₂O₂)-responsive antimicrobial dynamic covalent nano-networks (aDCNs) to form a new aDCNs/MnO₂@GOD nanogel dressing with multiple functions, such as hypoglycemic, anti-bacterial, anti-biofilm, anti-inflammatory, and promoting angiogenesis. The nanogel formation mechanism, physicochemical characterization, responsiveness release, in vitro and in vivo antimicrobial activities, in vivo regenerati

SUBMITTER: Luo W 

PROVIDER: S-EPMC12284566 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature