Cascade reaction-driven biomimetic scintillant/metal-organic frameworks for X-ray triggered combinational therapy against glioma.

ABSTRACT: Glioblastoma (GBM) is the most aggressive primary brain tumor with a grim prognosis and low survival rates. This unfavorable therapeutic outcome is partially because of the inadequate immune infiltration and an immunosuppressive microenvironment, which compromises the effectiveness of conventional radiotherapy (RT) and chemotherapy. Inducing immunogenic cell death (ICD) to modulate the antitumor immune response has emerged as a highly promising therapeutic strategy for GBM. Herein, we report the development of a novel radiodynamic therapy agent via an in situ growth strategy. This innovative agent integrates a porphyrin-hafnium metal-organic framework (MOF) with lanthanide scintillator nanoparticles (SNPs). Upon exposure to RT, the SNPs emit light, consequently activating the porphyrin pho

SUBMITTER: Wang L 

PROVIDER: S-EPMC12284571 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature