Exploring the Impact of Phenanthroline-Based Glycoconjugated Ru(II) Polypyridyl Photosensitizers on Metastasis-Related Processes.

ABSTRACT: Novel water-soluble, phosphorescent ruthenium(II) polypyridyl-glycoconjugates of general formula [Ru{N-(1,10-phenanthroline)}₂{N-(1,10-phenanthrolin-5-yl)-β-glycopyranosylamine}][Cl]₂ (glycopyranosyl = D-glucopyranosyl (1), D-mannopyranosyl (2), L-rhamnopyranosyl (3), L-xylopyranosyl (4), and 2,3,4-tri-O-acetyl-L-xylopyranosyl (5)) and corresponding aglycone [Ru{N-(1,10-phenanthroline)}₂{N-(1,10-phenanthrolin-5-amine)}][Cl]₂ (6) have been synthesized and fully characterized. Their stability and behavior in physiological media have been assessed using ultraviolet visible spectroscopy (UV-Vis) and ¹H nuclear magnetic resonance (¹H-NMR), revealing minor N-glycosidic cleavage and high photostability. The photocytotoxicity of the complexes

SUBMITTER: de la Torre-Rubio E 

PROVIDER: S-EPMC12284616 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature