Electrochemical Oxidative Radical Polar Crossover Route to 1,4-Keto Carboxylates Mediated by Anchimeric Assistance.

ABSTRACT: The 1,4-keto carboxylate scaffold is present in the structure of many biologically relevant compounds. To date, there are only a branch of methods to prepare them, using either transition metal catalysts, or noncommercially available and sensitive starting materials. Herein, we describe a sustainable electrochemical methodology starting from commercially available and highly stable 1,3-diketones and alkenes to prepare 1,4-keto aryl and alkyl carboxylates in a highly efficient manner, without the need of an external catalyst or harsh reaction conditions. This electrochemical oxidative radical polar crossover transformation presents a broad scope, is compatible with many functional groups, and can even be applied in flow chemistry. In addition, the key stabilization of the intermediate carbo

SUBMITTER: MacLean I 

PROVIDER: S-EPMC12284624 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature