Dual targeting of <i>CD155</i>/<i>TIGIT</i> and <i>PD-L1</i>/<i>PD-1</i> immune checkpoints potentiates NK cell-mediated cytotoxicity in medulloblastoma.

ABSTRACT:

Background

Medulloblastoma (MB) is one of the most prevalent pediatric brain malignancies and makes up approximately 20% of all primary brain tumors in children. Current treatment options are not curative for approximately 30% of patients and leave survivors with an impaired quality of life. Immune checkpoint inhibition can offer a novel targeted therapy but largely remains understudied in MB. The aim of this study was to determine whether dual immune checkpoint inhibition can be used as a novel targeted therapy in MB.

Methods

We utilized single cell and single nuclei sequencing datasets of primary MB tumors, established Group 3 and Sonic Hedgehog MB cell lines and MB patient-derived xenograft (PDX) organoid models, and primary patient-derived MB tissue of all subtypes to st

SUBMITTER: Monnikhof M 

PROVIDER: S-EPMC12284645 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature